Branched-chain amino acids sustain pancreatic cancer growth by regulating lipid metabolism
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چکیده
منابع مشابه
Branched Chain Amino Acids: Beyond Nutrition Metabolism.
Branched chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), play critical roles in the regulation of energy homeostasis, nutrition metabolism, gut health, immunity and disease in humans and animals. As the most abundant of essential amino acids (EAAs), BCAAs are not only the substrates for synthesis of nitrogenous compounds, they also serve as signaling mole...
متن کاملBranched-chain amino acid metabolism in cancer
PURPOSE OF REVIEW The current review aims to provide an update on the recent biomedical interest in oncogenic branched-chain amino acid (BCAA) metabolism, and discusses the advantages of using BCAAs and expression of BCAA-related enzymes in the treatment and diagnosis of cancers. RECENT FINDINGS An accumulating body of evidence demonstrates that BCAAs are essential nutrients for cancer growth...
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The three branched-chain amino acids (BCAAs) are the most hydrophobic of the amino acids and play crucial roles in determining the structures of globular proteins as well as the interaction of the transmembrane domains of membranous proteins with phospholipid bilayers. However, the three BCAAs do not behave identically. In terms of protein secondary structure, valine and isoleucine exhibit a de...
متن کاملBranched-Chain Amino Acids: Metabolism, Physiological Function, and Application Lessons from Genetic Disorders of Branched-Chain Amino Acid Metabolism
Genetic disorders of BCAA metabolism produce amino acidopathies and various forms of organic aciduria with severe clinical consequences. A metabolic block in the oxidative decarboxylation of BCAA caused by mutations in the mitochondrial branched-chain a-keto acid dehydrogenase complex (BCKDC) results in Maple Syrup Urine Disease (MSUD) or branched-chain ketoaciduria. There are presently five kn...
متن کاملBranched-Chain Amino Acids: Metabolism, Physiological Function, and Application Assessment of Branched-Chain Amino Acid Status and Potential for Biomarkers
BCAAs are not synthesized in the body in humans, but they are crucial in protein and neurotransmitter synthesis. The protein anabolic role of BCAAs seems to be mediated not only by their important role as a promoter of the translation process (and possibly acting at the transcription level) but also by inhibition of protein degradation. Leucine may play a critical role in these signaling pathwa...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2019
ISSN: 1226-3613,2092-6413
DOI: 10.1038/s12276-019-0350-z